| Identification | Back Directory | [Name]
1H-Imidazo[4,5-c]pyridin-6-amine, 2-(2-furanyl)-1-methyl-N-(3,4,5-trimethoxyphenyl)- | [CAS]
1642839-27-7 | [Synonyms]
GRK5-IN-2
1H-Imidazo[4,5-c]pyridin-6-amine, 2-(2-furanyl)-1-methyl-N-(3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C20H20N4O4 | [MDL Number]
MFCD34470578 | [MOL File]
1642839-27-7.mol | [Molecular Weight]
380.4 |
| Chemical Properties | Back Directory | [Boiling point ]
561.1±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.33 mg/mL (219.06 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.61±0.50(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Biological Activity]
GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research[1]. | [References]
[1]. Axel Ullrich (Prof. Dr.), et al. Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators. EP2818472A1. |
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