| Identification | Back Directory | [Name]
BocNH-PEG12-CH2CH2NH2 | [CAS]
1642551-09-4 | [Synonyms]
NHBoc-PEG12-amine
BocNH-PEG12-CH2CH2NH2
Boc-N-amido-PEG12-amine
5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azatetracontanoic acid, 40-amino-, 1,1-dimethylethyl ester | [Molecular Formula]
C31H64N2O14 | [MDL Number]
MFCD31656921 | [MOL File]
1642551-09-4.mol | [Molecular Weight]
688.84 |
| Chemical Properties | Back Directory | [Boiling point ]
695.1±55.0 °C(Predicted) | [density ]
1.088±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
Boc-NH-PEG12-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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