| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]- | [CAS]
1639929-29-5 | [Synonyms]
Chromenone 1
2-(1H-1,2,4-Triazol-1-yl)-3-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]- | [Molecular Formula]
C18H10F3N3O2 | [MOL File]
1639929-29-5.mol | [Molecular Weight]
357.29 |
| Chemical Properties | Back Directory | [Boiling point ]
474.2±55.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
3.14±0.19(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
Chromenone 1 is a bone morphogenetic protein (BMP) signaling potentiator th at exerts its effect via negative TGFβ feedback loopsindependent of direct kinase inhibition. Chromenone 1 prevents cardiogenesis induction by 0.5 μM BMP inhibitor DMH1 (IC50 = 200 nM; mESC-Myh6-GFP) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts (ALP activity induction EC50 = 340 nM; E100% and Emax = induction by 7.5 and 50 ng/mL BMP-4respectively). |
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