| Identification | Back Directory | [Name]
Sigma-1 receptor antagonist 3 | [CAS]
1639220-17-9 | [Synonyms]
Sigma-1 receptor antagonist 3
Pyrimidine, 5-chloro-2-(4-fluorophenyl)-4-methyl-6-[3-(1-piperidinyl)propoxy]-
KcsA,Potassium Channel,inhibit,Sigma-1 receptor antagonist 3,Sigma 1 receptor antagonist 3,Inhibitor,Sigma Receptor,Sigma1 receptor antagonist 3 | [Molecular Formula]
C19H23ClFN3O | [MDL Number]
MFCD32215324 | [MOL File]
1639220-17-9.mol | [Molecular Weight]
363.86 |
| Chemical Properties | Back Directory | [Boiling point ]
415.9±45.0 °C(Predicted) | [density ]
1.196±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 12.5 mg/mL (34.35 mM) | [form ]
Solid | [pka]
8.95±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 has the potential for the neuropathic pain[1]. | [IC 50]
Sigma 1 Receptor | [References]
[1] Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23. DOI:10.1021/jm501207r |
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