| Identification | Back Directory | [Name]
c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS | [CAS]
1638750-95-4 | [Synonyms]
ADU-S100
(MIW815)
MIW815 disodium salt
ADU-S100 disodium salt
ML RR-S2 CDA Sodium Salt
ML RR-S2 CDA disodium salt
c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS | [Molecular Formula]
C20H25N10NaO10P2S2 | [MOL File]
1638750-95-4.mol | [Molecular Weight]
714.54 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water: 100 mg/mL (136.15 mM; ultrasonic and adjust pH to 7 with NaOH) |
| Hazard Information | Back Directory | [Uses]
ML RR-S2 CDA sodium salt is used as a cyclic dinucleotide used in the treatment of cancer. It activates dendritic cells which induces a specific T-cell mediated immune response against cancer cells. | [in vivo]
2’3’-c-di-AM(PS)2 (Rp,Rp) shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the 2’3’-c-di-AM(PS)2 (Rp,Rp) compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%[1]. | [storage]
Store at -20°C |
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BOC Sciences
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16314854226 |
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www.bocsci.com |
| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
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