| Identification | Back Directory | [Name]
FIIN-2 | [CAS]
1633044-56-0 | [Synonyms]
FIN-2
FIIN-2
CS-1618
FIIN2;FIIN-2;FIIN 2
inhibit,FGFR,FIIN2,FIIN 2,Fibroblast growth factor receptor,Inhibitor,FIIN-2
N-[4-[[3-(3,5-Dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide
2-Propenamide, N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]- | [Molecular Formula]
C35H38N8O4 | [MDL Number]
MFCD28386553 | [MOL File]
1633044-56-0.mol | [Molecular Weight]
634.73 |
| Chemical Properties | Back Directory | [density ]
1.306±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥31.75 mg/mL in DMSO; insoluble in H2O; ≥3.39 mg/mL in EtOH with gentle warming | [form ]
solid | [pka]
13.51±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
FIIN-2 is an irreversible FGFR inhibitor with IC50 values of 3.09, 4.3, 27, and 45.3 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. It has been shown to inhibit cell proliferation of transformed Ba/F3 cell lines and demonstrates antiproliferative activity in cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2. By inhibiting FGFR in a zebrafish developmental model, FIIN-2 caused mild to severe alterations in tail morphogenesis similar to the phenotypes reported following genetic knockdown of FGFR. | [Uses]
FIIN 2 is FGFR inhibitor. It can be used in biological study of DFG-out mode of inhibition by an irreversible Type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors | [storage]
Store at -20°C |
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