| Identification | Back Directory | [Name]
PNZ5 | [CAS]
1629277-36-6 | [Synonyms]
PNZ5
PNZ5,PNZ-5
1H-Isoindol-1-one, 5-(3,5-dimethyl-4-isoxazolyl)-2,3-dihydro-2-methyl-3-phenyl-, (3S)- | [Molecular Formula]
C20H18N2O2 | [MDL Number]
MFCD32174233 | [MOL File]
1629277-36-6.mol | [Molecular Weight]
318.37 |
| Hazard Information | Back Directory | [Description]
PNZ5 is a potent and isoxazole-based pan-BET inhibitor with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4(1)[1].
BRD4(1)|5.43 nM (Kd)
| [storage]
Store at -20°C | [References]
[1]. Montenegro RC, et al. BET inhibition as a new strategy for the treatment of gastric cancer. Oncotarget. 2016 Jul 12;7(28):43997-44012. |
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