| Identification | Back Directory | [Name]
KDM5-IN-1 | [CAS]
1628210-26-3 | [Synonyms]
KDM5-IN-1
KDM5-IN-48
KDM5 inhibitor 1
KDM5 inhibitor compound 48
KDM5 IN 1,inhibit,Histone Demethylase,Inhibitor,KDM-5-IN-1,KDM5IN1
5-(1-tert-butyl-1H-pyrazol-4-yl)-7-oxo-6-(propan-2-yl)-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5-[1-(1,1-dimethylethyl)-1H-pyrazol-4-yl]-4,7-dihydro-6-(1-methylethyl)-7-oxo- | [Molecular Formula]
C17H20N6O | [MDL Number]
MFCD30747843 | [MOL File]
1628210-26-3.mol | [Molecular Weight]
324.38 |
| Chemical Properties | Back Directory | [Boiling point ]
527.0±60.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 30 mg/mL (92.48 mM) | [form ]
Solid | [pka]
3.10±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM. | [in vivo]
When dosed orally in mice at 50 mg/kg twice a day, KDM5-IN-1 shows an unbound maximal plasma concentration Cmax>15-fold over its cell EC50, thereby providing a robust chemical probe for studying KDM5 biological functions in vivo[1]. | [IC 50]
KDM5 | [storage]
Store at -20°C | [References]
[1] Liang J, et al. Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41. DOI:10.1016/j.bmcl.2016.06.078 |
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