| Identification | Back Directory | [Name]
B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid | [CAS]
1627917-17-2 | [Synonyms]
NDPBA
CUSTOMS SYNTHESIS
naphtho[2,3-b]benzofuran-2-ylboronic acid
naphtho[2,3-b][1]benzofuran-2-ylboronic acid
Benzo[b]naphtho[2,3-d]furan-2-ylboronic acid
B-benzo[b]naphtha[2,3-d]furan-2-yl-boronic acid
B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid
Boronic acid,B-benzo[b]naphtho[2,3-d]furan-2-yl- | [Molecular Formula]
C16H11BO3 | [MDL Number]
MFCD30187284 | [MOL File]
1627917-17-2.mol | [Molecular Weight]
262.07 |
| Hazard Information | Back Directory | [Uses]
B-benzo[b]naphtho[2,3-d]furan-2-yl-boronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | [Synthesis]
12.6g of intermediate (A) and 500 mL of tetrahydrofuran (dehydrated) were put in a flask, and the resultant
was cooled to -78°C. 28 mL of n-BuLi (1.60M in hexane) was added, and stirring was conducted for 2 hours while
elevating the temperature to 0°C. Then, the solution was again cooled to -78°C, and 11.6g of B(OMe) 3 was added. After
stirring at 10 minutes at -78°C, stirring was further conducted for 5 hours while gradually elevating the temperature to
room temperature. After completion of the reaction, 1 N HCl aq. (100 mL) was added, and the reaction solution was stirred at room
temperature for 1 hour. Then, the solution was transferred to a separating funnel, and extracted with ethyl acetate. This solution was dried with MgSO 4, concentrated and washed with hexane, whereby 7.2g (yield: 65%) of white
solids of intermediate (B) were obtained. |
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