| Identification | Back Directory | [Name]
ALLOPURINOL RIBOSIDE | [CAS]
16220-07-8 | [Synonyms]
ALLOPURINOL RIBOSIDE
8-AZA-7-DEAZAINOSINE
Allopurinol ribonucleoside
Allopurinol-1-ribonucleoside
1-BETA-D-RIBOFURANOSYLPYRAZOLO[3,4-D]PYRIMIDIN-4-ONE
1-β-d-ribofuranosyl-1h-pyrazolo[3,4-d]pyrimidine-4-one
1-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE-4-ONE
1,5-Dihydro-1-β-D-ribofuranosyl-4H-pyrazolo[3,4-d]pyrimidin-4-one
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-
1-[(2S,3S,4R,5R)-3,4,5,6-tetrahydroxyoxan-2-yl]-2H-pyrazolo[4,5-e]pyrimidin-4-one | [Molecular Formula]
C10H12N4O5 | [MDL Number]
MFCD00057096 | [MOL File]
16220-07-8.mol | [Molecular Weight]
268.23 |
| Chemical Properties | Back Directory | [Boiling point ]
715.0±60.0 °C(Predicted) | [density ]
2.08±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO:5.0(Max Conc. mg/mL);18.64(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);18.64(Max Conc. mM) | [form ]
A solid | [pka]
8.65±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Allopurinol riboside is a structural isomer of hypoxanthine. | [Definition]
ChEBI: A nucleoside analogue that is allopurinol with a beta-D-ribofuranosyl moiety at the 1-position. | [in vivo]
Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 hours, and steady-state concentrations in the therapeutic range[3]. After oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma[4]. | [IC 50]
Leishmania |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
m.is0513.com/showsupplierproductslist1701258/0.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|