| Identification | Back Directory | [Name]
TCO-PEG4-NHS Ester | [CAS]
1621096-79-4 | [Synonyms]
TCO4-PEG4-NHS
TCO-PEG4-NHS Ester,Trans-Cyclooctene-PEG4-NHS ester
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4E)-4-cycloocten-1-yl 17-(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C24H38N2O10 | [MOL File]
1621096-79-4.mol | [Molecular Weight]
514.57 |
| Hazard Information | Back Directory | [Uses]
TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. | [IC 50]
PEGs | [References]
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1013. DOI:10.1016/j.chembiol.2020.07.021 |
|
|