| Identification | Back Directory | [Name]
UNC0379 (trifluoroacetate) | [CAS]
1620401-83-3 | [Synonyms]
UNC0379 TFA
UNC0379 (trifluoroacetate)
UNC0379 trifluoroacetate salt >=98% (HPLC) | [Molecular Formula]
C25H36F3N5O4 | [MOL File]
1620401-83-3.mol | [Molecular Weight]
527.59 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
Light yellow to khaki | [Water Solubility ]
H2O: 5mg/mL, clear |
| Hazard Information | Back Directory | [Biological Activity]
SETD8 expression is observed in cancers such as bladder cancerchronic myelogenous leukemiahepatocellular carcinomanon‐small‐cell lung carcinomaprostate cancersmall‐cell lung carcinoma. Therefore inhibition of SETD8 (SET‐domain containing protein) by UNC0379 might prevent the progression of cancer.''UNC0379 is the first substrate-competitive inhibitor of the lysine methyltransferase SETD8the only known methyltransferase th at catalyzes monomethylation of histone H4 lysine 20 (H4K20). HK420 methylation has been implicated in the regulation of a variety of biological processes including the DNA damage response. UNC0379 is selective for SETD8 over 15 other methyltransferaseswith an IC50 value of 7.3 μM for SETD8 compared to IC50 vlaues over 100 μM for other methyltransferases. | [storage]
Store at -20°C |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|