| Identification | Back Directory | [Name]
Acetic acid, 2,2-dichloro-, 2'-[(2,2-dichloroacetyl)oxy]-3,5'-di-2-propen-1-yl[1,1'-biphenyl]-4-yl ester | [CAS]
1620160-42-0 | [Synonyms]
Honokiol DCA
Honokiol Bis-Dichloroacetate
Acetic acid, 2,2-dichloro-, 2'-[(2,2-dichloroacetyl)oxy]-3,5'-di-2-propen-1-yl[1,1'-biphenyl]-4-yl ester | [Molecular Formula]
C22H18Cl4O4 | [MDL Number]
MFCD34469330 | [MOL File]
1620160-42-0.mol | [Molecular Weight]
488.19 |
| Chemical Properties | Back Directory | [Boiling point ]
537.9±50.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level[1].
Honokiol DCA (20-40 μM; 24-48 h) inhibits the viability of LNCaP and C4-2 cells in a dose-and time-dependent manner[1].Honokiol DCA (5-20 μM; 10 days) inhibits clonogenicity of prostate cancer cells[1].Honokiol DCA (20-40 μM; 24-48 h) significantly decreases the level of androgen receptor (AR) and prostate specific antigen (PSA) protein in LNCaP cells[1].Honokiol DCA (40 μM; 24 h) significantly decreases AR promoter activity in LNCaP and C4-2 cells[1].
Honokiol類似物 | [storage]
Store at -20°C | [References]
[1]. Hahm ER, et, al. Honokiol inhibits androgen receptor activity in prostate cancer cells. Prostate. 2014 Apr;74(4):408-20. |
|
|