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ChemicalBook--->CAS DataBase List--->1613752-50-3

1613752-50-3

1613752-50-3 Structure

1613752-50-3 Structure
IdentificationBack Directory
[Name]

Propargyl-PEG8-CH2CH2COOH
[CAS]

1613752-50-3
[Synonyms]

Propargyl-PEG8-CH2CH2COOH
[Molecular Formula]

C22H40O11
[MDL Number]

MFCD31656984
[MOL File]

1613752-50-3.mol
[Molecular Weight]

480.55
Hazard InformationBack Directory
[Biological Activity]

Propargyl-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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