| Identification | Back Directory | [Name]
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) | [CAS]
1613465-33-0 | [Synonyms]
ML-336
2-[(1,4-Dimethylpiperazin-2-ylidene)amino]-5-nitro-N-phenylbenzamide
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide
Benzamide, 2-[(E)-(1,4-dimethyl-2-piperazinylidene)amino]-5-nitro-N-phenyl-
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) | [Molecular Formula]
C19H21N5O3 | [MDL Number]
MFCD28160682 | [MOL File]
1613465-33-0.mol | [Molecular Weight]
367.4 |
| Chemical Properties | Back Directory | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≤0.2mg/ml in ethanol;10mg/ml in DMSO;20mg/ml in dimethyl formamide | [form ]
crystalline solid | [pka]
12.30±0.70(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Biological Activity]
ml-336 is an inhibitor for veev-induced cytopathic effect.alphaviruses like venezuelan equine encephalitis virus (veev) are positive-sense, enveloped, single stranded rna viruses that are widely geographically distributed. veevs are found to be arthropod-borne viruses that are known to cause arthritis, encephalitis, rash, as well as death in humans. | [in vitro]
ml336 was identified as a first-in-class probe that inhibited a veev-induced cytopathic effect in three strains of the virus, which were v3526, tc-83, and trinidad donkey, in the low nanomolar range without having cytotoxicity (> 50 μm, selectivity index > 1500). in addition, ml336 could reduce viral titer (more than 7.2 log) dramatically below a 1 μm drug concentration. furthermore, ml336 showed a favorable in vitro pk profile that included moderate blood-brain barrier permeability. more importantly, ml336 seemed to be able to target the veev [1]. | [IC 50]
32, 20, and 41 nm for tc-83, v3526, and trinidad donkey strains, respectively. | [References]
[1] chung d et al. ml336: development of quinazolinone-based inhibitors against venezuelan equine encephalitis virus (veev). probe reports from the nih molecular libraries program. bethesda (md): national center for biotechnology information (us); 2010-2012 dec 17. |
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