| Identification | Back Directory | [Name]
7,8-dibromo-9-methyl-2-(piperazin-1-yl)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline hydrochloride | [CAS]
1609452-30-3 | [Synonyms]
SEL120-34A HCl
SEL120-34A hydrochloride
7,8-dibromo-9-methyl-2-(piperazin-1-yl)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline hydrochloride
SEL12034A HCl,SEL120-34A HCl,CDK,SEL-120-34A HCl,Inhibitor,SEL120 34A HCl,Cyclin dependent kinase,inhibit | [Molecular Formula]
C15H19Br2ClN4 | [MOL File]
1609452-30-3.mol | [Molecular Weight]
450.599 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:31.75(Max Conc. mg/mL);70.46(Max Conc. mM)
Water:90.0(Max Conc. mg/mL);199.73(Max Conc. mM) | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SEL120-34A hydrochloride is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. | [in vivo]
SEL120-34A (30, 60 mg/kg, p.o.) hydrochloride inhibits the growth of tumor in mice bearing MV4-11 cancer cells, and also arrests the growth of KG-1-derived tumors at 30 mg/kg via oral administration[1]. | [IC 50]
CDK8/CycC: 4.4 nM (IC50); CDK19/CycC: 10.4 nM (IC50); CDK9/cycT: 1070 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795. DOI:10.18632/oncotarget.16810 |
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Wuhan Topule
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+86-02787215551 +86-19945035818 |
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http://www.topule.com/ |
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cjbscvictory
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https://www.weikeqi-biotech.com/ |
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