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ChemicalBook--->CAS DataBase List--->1609258-91-4

1609258-91-4

1609258-91-4 Structure

1609258-91-4 Structure
IdentificationBack Directory
[Name]

PF-06412562
[CAS]

1609258-91-4
[Synonyms]

PF2562
PF-06412562
PF-06412562 >=98% (HPLC)
[Molecular Formula]

C19H17N5O
[MDL Number]

MFCD31558510
[MOL File]

1609258-91-4.mol
[Molecular Weight]

331.37
Chemical PropertiesBack Directory
[Boiling point ]

519.3±50.0 °C(Predicted)
[density ]

1.277±0.06 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

DMSO: 30mg/mL, clear
[form ]

powder
[pka]

11.41±0.40(Predicted)
[color ]

white to beige
Hazard InformationBack Directory
[Description]

PF2562 is a non-catechol dopamine 1 receptor agonist. Dopamine D1 receptors are implicated in numerous neuropharmacological and neurobiological functions. For example, D1 receptors are involved in different types of memory function and synaptic plasticity.
[Uses]

PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a Ki of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC50 of 568 nM in HTRF assay[1].
[References]

[1] Jennifer Elizabeth Davoren, et al. Heteroaromatic compounds and their use as dopamine d1 ligands. US20140128374A1.
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