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ChemicalBook--->CAS DataBase List--->159812-83-6

159812-83-6

159812-83-6 Structure

159812-83-6 Structure
IdentificationBack Directory
[Name]

ent-8-iso Prostaglandin F2α
[CAS]

159812-83-6
[Synonyms]

ent-8-iso Prostaglandin F2α
PXGPLTODNUVGFL-VCKDCIDJSA-N
ent-8-iso Prostaglandin F2.alpha.
[Molecular Formula]

C20H34O5
[MOL File]

159812-83-6.mol
[Molecular Weight]

354.481
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS (pH 7.2): 1 mg/ml
Hazard InformationBack Directory
[Description]

Isoprostanes are produced by the non-enzymatic, free radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but also have been found to have a potent biological activity. ent-8-iso Prostaglandin F2α (ent-8-iso PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 31 and 54 nM, respectively.1
[References]

1. Hou, X., Robers, L.J., II, Gobeil, F., Jr., et al. Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculature Free Radic. Biol. Med. 36(2),163-172(2004).
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