| Identification | Back Directory | [Name]
RYANODINE | [CAS]
15662-33-6 | [Synonyms]
ryania
Ryanex
ryanexel
RYANADOL
Ryanicide
RYANODINE
Ryanexcel
bonideryatox
ryaniapowder
Ryanodine,99%
ryaniaspeciosa
9,21-DEHYDRO(RG)
ryanodinealkaloid
RYANODINE MIXTURE
Ryania(content>30%)
RYANODINE HIGH PURITY
3-(1H-PYR-ROLE-2-CARBOXYLATE)
Ryanodine from Ryania speciosa
RYANODINE >98% (RYANADOL, 3-(1H-PYRR
RYANADOL 3-(1H-PYRROLE-2-CARBOXYLATE)
RYANODOL-3-(1H-PYRROLE-2-CARBOXYLATE)
RYANODINE FROM RYANIA SPECIOSA MINIMUM &
groundryaniaspecisa(vahl)stemwood(alkoloidryanodine)
Ryanodol 3-(1H-pyrrole-2-carboxylate) from Ryania speciosa
RYANODINE FROM RYANIA SPECIOSA A MIXTURE OF RYANODINE AND 9,21-DEHYDRORYANODINE (1:1)
RYANODINE FROM RYANIA SPECIOSA INHIBITS CALCIUM RELEASE FROM THE SARCOPLASMIC RETICULUM
1H-Pyrrole-2-carboxylicacid(3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethy]
6-(1α,5aβ,8aβ,9-pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate ryania
6-(1alpha,5abeta,8abeta,9-pentahydroxy-7beta-isopropyl-2beta,5beta,8beta-trimethylperhydro-8balpha,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate
1H-PYRROLE-2-CARBOXYLIC ACID, (3S,4R,4AR,6S,7S,8R,8AS,8BR,9S,9AS)-DODECAHYDRO-4,6,7,8A,8B,9A-HEXAHYDROXY-3,6A,9-TRIMETHYL-7-(1-METHYLETHYL)-6,9-METHANOBENZO[1,2]PENTALENO[1,6-BC]FURAN-8-YL ESTER | [EINECS(EC#)]
239-732-2 | [Molecular Formula]
C25H35NO9 | [MDL Number]
MFCD00151119 | [MOL File]
15662-33-6.mol | [Molecular Weight]
493.55 |
| Chemical Properties | Back Directory | [Appearance]
white to off-white solid | [alpha ]
D25 +26° (methanol) | [Boiling point ]
586.95°C (rough estimate) | [density ]
1.2805 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
White solid | [Melting point ]
219-220 °C | [pka]
10.66±0.70(Predicted) | [color ]
white to beige | [CAS DataBase Reference]
15662-33-6 | [EPA Substance Registry System]
Ryanodine (15662-33-6) |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white solid | [Definition]
ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa. | [Uses]
Insecticide. | [Biological Activity]
Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively). | [Description]
Ryania insecticide is the ground stem wood of the
tropical tree Ryania speciosa Vahl., and it contains over a
dozen of several structurally related alkaloids. Nowadays,
this botanical preparation is of minor importance, but
one of its major ingredients, ryanodine, is a widely used
pharmacological tool in studies of the calcium release
channels in sarcoplasmic reticulum membranes of skeletal
and cardiac muscle of both insects and mammals (11,12). | [storage]
Desiccate at -20°C | [References]
Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968) |
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