| Identification | Back Directory | [Name]
G244-LM | [CAS]
1563007-08-8 | [Synonyms]
G244-LM
4H-Thiopyrano[4,3-d]pyrimidin-4-one, 3,5,7,8-tetrahydro-2-[4-[2-(methylsulfonyl)phenyl]-1-piperazinyl]- | [Molecular Formula]
C18H22N4O3S2 | [MOL File]
1563007-08-8.mol | [Molecular Weight]
406.52 |
| Chemical Properties | Back Directory | [Boiling point ]
662.4±65.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF:2.0(Max Conc. mg/mL);4.92(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);12.3(Max Conc. mM)
Ethanol:0.25(Max Conc. mg/mL);0.615(Max Conc. mM) | [form ]
A crystalline solid | [pka]
2.83±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
G244-LM is an inhibitor of Wnt signaling. | [Uses]
G244-LM is a potent and specific inhibitor of tankyrase 1/2 that inhibits Wnt signaling[1]. | [storage]
Store at -20°C | [References]
[1] Lau T, et al. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res. 2013 May 15;73(10):3132-44. DOI:10.1158/0008-5472.CAN-12-4562 |
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