| Identification | Back Directory | [Name]
ONO EI-601 | [CAS]
155023-59-9 | [Synonyms]
ONO EI-601
Sivelestat Impurity 2
Glycine, N-[2-[[(4-hydroxyphenyl)sulfonyl]amino]benzoyl]- | [Molecular Formula]
C15H14N2O6S | [MOL File]
155023-59-9.mol | [Molecular Weight]
350.35 |
| Hazard Information | Back Directory | [Description]
Ono EI-601 is the main metabolite of the human neutrophil elastase inhibitor ONO-5046. In plasma and urine by direct injection column-switching HPLC proved to be useful for pharmacokinetic, toxicological and clinical studies. | [Uses]
ONO-EI-601 is the major metabolite of human neutrophil elastase inhibitor ONO-5046. ONO-5046 has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1]. | [References]
[1] Shintani T, et al. Simultaneous determination of human neutrophil elastase inhibitor (ONO-5046) and its metabolite in plasma and urine by direct injection column-switching HPLC. J Pharm Biomed Anal. 1994 Mar;12(3):397-405. DOI:10.1016/0731-7085(94)90017-5 |
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