| Identification | Back Directory | [Name]
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate | [CAS]
15427-93-7 | [Synonyms]
DDUG diMS
NSC 109555
NSC109555 Dimesylate
NSC 109555 ditosylate
DDUG dimethanesulfonate
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2) | [Molecular Formula]
C20H28N10O4S | [MOL File]
15427-93-7.mol | [Molecular Weight]
504.566 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble5mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 5mg/mL, clear (warmed) |
| Hazard Information | Back Directory | [Uses]
NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be b
eneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caus
ed acute paralysis leading to apnea and death. | [Uses]
NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death. | [Biochem/physiol Actions]
NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM. | [storage]
Store at -20°C |
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