| Identification | Back Directory | [Name]
ANQ 11125 | [CAS]
153966-48-4 | [Synonyms]
ANQ 11125
1-14-Motilin (swine), 3-L-phenylalanine-13-L-leucine- (9CI) | [Molecular Formula]
C86H125N19O21 | [MDL Number]
MFCD27991292 | [MOL File]
153966-48-4.mol | [Molecular Weight]
1761.03 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
solid | [color ]
White |
| Hazard Information | Back Directory | [Biological Activity]
anq 11125 is a selective antagonist of motilin receptor with pkd of 8.24 [1].motilin receptor is a g protein-coupled receptor for motilin and stimulates contraction of gut smooth muscle.anq 11125 is a selective motilin receptor antagonist. the affinity of anq 11125 for motilin receptor is about 10 times less than motilin [1]. in rabbit antral smooth muscle tissue, anq-11125 bound to motilin receptor with pkd value of 8.16. while, anq-11125 didn’t induce contractions of rabbit duodenum. anq-11125 (10-5 m) induced contractile response by 29% compared to ach [2]. | [storage]
Store at -20°C | [References]
[1]. depoortere i, macielag mj, galdes a, et al. antagonistic properties of [phe3,leu13]porcine motilin. eur j pharmacol, 1995, 286(3): 241-247.
[2]. peeters tl, depoortere i, macielag mj, et al. the motilin antagonist anq-11125 blocks motilide-induced contractions in vitro in the rabbit. biochem biophys res commun, 1994, 198(2): 411-416. |
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BOC Sciences
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https://www.bocsci.com |
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