| Identification | Back Directory | [Name]
Lanicemine dihydrochloride | [CAS]
153322-06-6 | [Synonyms]
AZD6765
ARL-15896
Lanicemine 2HCl
AZD6765 dihydrochloride
Lanicemine hydrochloride
FPL 15896 dihydrochloride
Lanicemine dihydrochloride
AR-R 15896 dihydrochloride
AZD6765 dihydrochloride >=97% (HPLC)
(αS)-α-Phenyl-2-pyridineethanamine dihydrochloride
ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR | [Molecular Formula]
C13H16Cl2N2 | [MOL File]
153322-06-6.mol | [Molecular Weight]
234.73 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [optical activity]
[α]/D +77 to +90°, c =1 in methanol | [Water Solubility ]
H2O: 20mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
AZD6765 dihydrochloride has been used as an antidepressant?to improve behavior and metabolic measures?in chronic unpredictable mild stress (CUMS). | [Biochem/physiol Actions]
AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant. In a recent study AZD6765 relieved depression within 80 minutes, unlike most antidepressants acting on serotonin or dopamine systems which can take several weeks to work. The effects lasted from about an hour up to 2 weeks. AZD6765 has an IC50 value of 1.3 μM. Unlike more potent drugs such as ketamine, which also has rapid antidepressant activity, AZD6765 has no dissociative side-effects such as hallucinations. Earlier studies inidcated the compound has neuroprotective and anticonvulsant effects. | [storage]
Store at -20°C |
|
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