| Identification | Back Directory | [Name]
LaniceMine | [CAS]
153322-05-5 | [Synonyms]
LaniceMine
2-PyridineethanaMine, a-phenyl-, (aS)-
(1S)-1-phenyl-2-pyridin-2-ylethanamine
2-Pyridineethanamine, α-phenyl-, (αS)-
(S)-1-phenyl-2-(pyridin-2-yl)ethanamine
(1S)-1-PHENYL-2-(PYRIDIN-2-YL)ETHAN-1-AMINE | [Molecular Formula]
C13H14N2 | [MDL Number]
MFCD00924222 | [MOL File]
153322-05-5.mol | [Molecular Weight]
198.26 |
| Chemical Properties | Back Directory | [Boiling point ]
307.7±27.0 °C(Predicted) | [density ]
1.097±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≤20mg/ml in ethanol;30mg/ml in DMSO;5mg/ml in dimethyl formamide | [form ]
neat oil | [pka]
8.29±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 μM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 μM. Compared to ketamine , lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate. It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity. | [Uses]
Lanicemine is a non-selective voltage-dependant NMDA channel blocker. It is a potential anti-depressant which does not cause psychotomimetic activity. Potential anti-hypertensive agent. | [in vitro]
previous study with lanicemine and ketamine found that both compounds could bind with low-to-moderate affinity to sites within the nmda channel pore, exhibit strong voltage dependence, and have similar lack of nr2a vs nr2b subunit selectivity [1]. | [in vivo]
in animal study, cortical eeg recordings were obtained from rats trained to perform an auditory detection task for food reward. results showed that both lanicemine and ketamine produced pronounced dose-dependent elevations in spontaneous gamma-band eeg, but only gamma changes for ketamine were tightly coupled to increases in locomotor activity, indicating that lanicemine not only engaged brain circuits involved in the generation of gamma-eeg, but also influenced these networks independent of the broader systemslevel disruptions typical of ketamine [1]. | [IC 50]
4-7 μm | [storage]
Store at -20°C | [References]
[1] g. sanacora, m. a. smith, s. pathak, et al. lanicemine: a low-trapping nmda channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. molecular psychiatry 19(9), 978-985 (2014). |
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Energy Chemical
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