| Identification | Back Directory | [Name]
TGR-1202 (hydrochloride) | [CAS]
1532533-78-0 | [Synonyms]
Umbralisib HCl
RP5264 hydrochloride
RP-5264 hydrochloride
RP 5264 hydrochloride
Umbralisib hydrochloride
TGR-1202 (hydrochloride)
Umbralisib (TGR-1202) HCl
TGR-1202 hydrochloride(Umbralisib)
Umbralisib (TGR-1202) hydrochloride
RP5264 HYDROCHLORIDE; TGR1202 HYDROCHLORIDE; TGR 1202 HYDROCHLORIDE; RP-5264 HYDROCHLORIDE; RP 5264 HYDROCHLORIDE | [Molecular Formula]
C31H25ClF3N5O3 | [MOL File]
1532533-78-0.mol | [Molecular Weight]
608.02 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 150 mg/mL (246.71 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
2-?[(1S)?-?1-?[4-?Amino-?3-?[3-?fluoro-?4-?(1-?methylethoxy)?phenyl]?-?1H-?pyrazolo[3,?4-?d]?pyrimidin-?1-?yl]?ethyl]?-?6-?fluoro-?3-?(3-?fluorophenyl)?-4H-?1-?benzopyran-?4-?one Hydrochloride (1:1) is a drug candidate. It is used in the preparation of 1H-Pyrazolo[3,4-d]pyrimidine derivatives as selective PI3K delta inhibitors for treatment of autoimmune and inflammatory disorders, and proliferative diseases such as cancer. | [in vivo]
Umbralisib hydrochloride (150 mg/kg, daily p.o.) significantly shrinks the tumors by day 25 in a subcutaneous xenograft model of T-cell acute lymphoblastic leukemia (T-ALL) in NOD/SCID mice using the MOLT-4 cell line[4]. | [IC 50]
PI3Kδ: 22.2 nM (EC50); PI3Kδ: 6.2 nM (Kd); PI3Kγ: 1400 nM (Kd); PI3Kβ: >10000 nM (Kd); PI3Kα: >10000 nM (Kd) | [storage]
Store at -20°C |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|