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ChemicalBook--->CAS DataBase List--->153190-29-5

153190-29-5

153190-29-5 Structure

153190-29-5 Structure
IdentificationBack Directory
[Name]

U-74389G
[CAS]

153190-29-5
[Synonyms]

U-74389G
(Z)-2-BUTENEDIONATE
DESMETHYL TIRILAZAD
METHYLATED TIRILAZAD
ABCSSKWSUJMJCP-WQDFMEOSSA-N
21-(4-(2,6 DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE
21-[4-(4,6-DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL]-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE MALEATE
21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]-triene-3,20-dione maleate salt
21-(4-(2,6-DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE (Z)-2-BUTENEDIOATE
21-(4-(2,6 DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE (Z)-2-BUTENEDIONATE
(8S,10S,13S,14S,17S)-17-(2-(4-(2,6-Di(pyrrolidin-1-yl)pyrimidin-4-yl)piperazin-1-yl)acetyl)-10,13-dimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one maleate
[Molecular Formula]

C41H54N6O6
[MDL Number]

MFCD01074991
[MOL File]

153190-29-5.mol
[Molecular Weight]

726.9
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,Store in freezer, under -20°C
[solubility ]

ethanol: soluble20 mg/mL, clear, light yellow
[form ]

White solid.
[color ]

White
[Sensitive ]

Hygroscopic
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.
[Uses]

U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation.
[References]

1) Braughler et al. (1987) Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation; J. Biol. Chem., 262 10438 2) Campo et al. (1996) Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation; J. Pharmacol. Exp. Ther., 277 333 3) Perna et al. (1996) Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G; Pharmacol. Res., 34 25
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