| Identification | Back Directory | [Name]
KF 17837 | [CAS]
152881-18-0 | [Synonyms]
KF 17837
KF 17837S
8-(3,4-Dimethoxyphenyl)-7-methyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
1H-Purine-2,6-dione,8-(3,4-diMethoxyphenyl)-3,7-dihydro-7-Methyl-1,3-dipropyl | [Molecular Formula]
C20H26N4O4 | [MDL Number]
MFCD22493499 | [MOL File]
152881-18-0.mol | [Molecular Weight]
386.44 |
| Hazard Information | Back Directory | [Description]
KF 17837S is an adenosine A(2a) receptor antagonists, which is potential therapeutic and neuroprotective effects in Parkinson's disease. | [in vitro]
The novel A2A receptor antagonist, (E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine (KF 17837), blocked the CGS 21680 (1 nM)-induced inhibition of [3H]-GABA efflux with an EC50 of approximately 30 nM and also antagonized the CGS 21680 (0.1 nM)-induced stimulation of [3H]-ACh release with an EC50 of approximately 0.3 nM._x000D_
_x000D_
Reference: Br J Pharmacol. 1994 Sep;113(1):43-8. https://pubmed.ncbi.nlm.nih.gov/7812630/ | [in vivo]
Autoradiographic study of [3H]KF17837S binding using rat brain sections revealed that the binding site was highly enriched in the striatal region. These data indicate that [3H] KF17837S labels the adenosine A2A receptor in rat brain._x000D_
_x000D_
Reference: Mol Pharmacol. 1994 Nov;46(5):817-22. https://pubmed.ncbi.nlm.nih.gov/7969067/ | [target]
KF 17837S is an adenosine A(2a) receptor antagonists. |
|
| Company Name: |
Matrix Scientific
|
| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
|