| Identification | Back Directory | [Name]
KRN4884 | [CAS]
152802-84-1 | [Synonyms]
KRN4884
3-Pyridinecarboximidamide, 5-amino-N-[2-(2-chlorophenyl)ethyl]-N'-cyano- | [Molecular Formula]
C15H14ClN5 | [MDL Number]
MFCD00923724 | [MOL File]
152802-84-1.mol | [Molecular Weight]
299.76 |
| Chemical Properties | Back Directory | [Boiling point ]
520.0±60.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
3.54±0.22(Predicted) |
| Hazard Information | Back Directory | [Uses]
KRN4884 is a K+ channel opener. In the presence of intracellular ATP (1 mM), KRN4884 (0.1-3 μM) activates KATP channels in a concentration-dependent manner (EC50=0.55 μM). | [in vivo]
The effects of KRN4884, a novel pyridinecarboxamidine type KATP channel opener, on serum triglyceride levels are investigated in Sprague-Dawley rats. Oral administration of KRN4884 (3 mg/kg) for 10 days causes a significant reduction in serum triglyceride levels, which is comparable to that of Clofibrate (160 mg/kg). Reduction in serum triglyceride levels by KRN4884 and Clofibrate are accompanied by a reduction in triglyceride levels both in chylomicron and in very low density lipoprotein. KRN4884 treatment does not affect serum concentrations of total cholesterol and phospholipid, but increases free fatty acid levels. Rats receiving KRN4884 exhibite an increase in lipoprotein lipase (LPL) activity both in adipose tissue and in skeletal muscle[2]. | [storage]
Store at -20°C | [References]
[1] Shinbo A, et al. Activation of cardiac ATP-sensitive K+ channels by KRN4884, a novel K+ channel opener. J Pharmacol Exp Ther. 1997 Nov;283(2):770-7. PMID:9353397
[2] Yokoyama T, et al. Effects of KRN4884, a novel pyridinecarboxamidine type KATP channel opener, on serum triglyceride levels in rats. Br J Pharmacol. 1997 Apr;120(8):1471-6. DOI:10.1038/sj.bjp.0701077 |
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BOC Sciences
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https://www.bocsci.com |
| Company Name: |
MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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