| Identification | Back Directory | [Name]
2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran
2-[2-(2-溴乙氧基)乙氧基]四氫-2H-吡喃 | [CAS]
152065-54-8 | [Synonyms]
Br-PEG2-THP
2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran | [Molecular Formula]
C9H17BrO3 | [MDL Number]
MFCD29049404 | [MOL File]
152065-54-8.mol | [Molecular Weight]
253.13 |
| Hazard Information | Back Directory | [Uses]
Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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