| Identification | Back Directory | [Name]
RO-32-0432 | [CAS]
151342-35-7 | [Synonyms]
RO-32-0432
Ro 31-0432
RO 32-0432 HCL
RO 32-0432 HYDROCHLORIDE
BISINDOLYLMALEIMIDE XI, HCL
BISINDOLYLMALEIMIDE XL, HCL
BISINDOYLMALEIMIDE XI HYDROCHLORIDE
BISINDOLYLMALEIMIDE XI HYDROCHLORIDE
BisindolylMaleiMide XI . hydrochloride [Ro 32-0432]
2-[8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, HCL
2-(8-[(DIMETHYLAMINO)METHYL]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-3-YL)-3-(1-METHYLINDOL-3-YL)MALEIMIDE HYDROCHLORIDE
(S)-3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-
1H-Pyrrol-2,5-dione, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropy rido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-, (S)-
Bisindoylmaleimide XI: 2-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl)-3-(1-methylindol-3-yl)maleimide
3-[8-[(DiMethylaMino)Methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione Hydrochloride
3-[(8S)-8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride | [Molecular Formula]
C28H28N4O2 | [MDL Number]
MFCD01319127 | [MOL File]
151342-35-7.mol | [Molecular Weight]
452.55 |
| Chemical Properties | Back Directory | [Boiling point ]
712.2±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO: soluble | [form ]
solid | [pka]
7.91±0.60(Predicted) | [color ]
orange |
| Hazard Information | Back Directory | [Uses]
Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has
been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl
ammatory responses in vivo. | [Biological Activity]
Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo . |
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| Company Name: |
Alfa Chemistry
|
| Tel: |
+1 (201) 478-8534 |
| Website: |
www.alfa-chemistry.com |
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