| Identification | Back Directory | [Name]
bottromycin A(2) | [CAS]
15005-62-6 | [Synonyms]
bottromycin A(2)
b-Alanine, N-[(2S)-2-[[glycyl-(3R)-3-methyl-Lprolyl-L-valyl]amino]-1-imino-3,3-dimethylbutyl]-3-methyl-L-valyl-(bS)-b-methyl-L-phenylalanyl-3-(2-thiazolyl)-, methyl ester, cyclic (1')-imine,(3R)-
β-Alanine, N-[(2S)-2-[[glycyl-(3R)-3-methyl-L-prolyl-L-valyl]amino]-1-imino-3,3-dimethylbutyl]-3-methyl-L-valyl-(βS)-β-methyl-L-phenylalanyl-3-(2-thiazolyl)-, methyl ester, cyclic (1→1')-imine, (3R)- | [Molecular Formula]
C42H62N8O7S | [MDL Number]
MFCD34166124 | [MOL File]
15005-62-6.mol | [Molecular Weight]
823.07 |
| Chemical Properties | Back Directory | [Boiling point ]
1061.3±65.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Ether: soluble,Methanol: soluble, | [form ]
A solid | [pka]
12.18±0.46(Predicted) | [Water Solubility ]
Water: soluble |
| Hazard Information | Back Directory | [Uses]
Bottromycin A2 is a natural antibiotic. Bottromycin A2 is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE)[1]. | [Biological Activity]
Bottromycin A2 is an antibiotic originally isolated from Streptomyces.1 It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2 Bottromycin A2 is active against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci with MIC values of 1 and 0.5 μg/ml, respectively. | [References]
1.Nakamura, S., Yajima, T., Lin, Y., et al.Isolation and characterization of bottromycins A2, B2, C2J. Antibiot. (Tokyo)20(1)1-5(1967)
2.Gouda, H., Kobayashi, Y., Yamada, T., et al.Three-dimensional solution structure of bottromycin A2: A potent antibiotic active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant EnterococciChem. Pharm. Bull. (Tokyo)60(2)169-171(2012)
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ChemeGen 中國
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18818260767 |
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https://www.chemegen.com |
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