| Identification | Back Directory | [Name]
RS 23597-190 HYDROCHLORIDE | [CAS]
149719-06-2 | [Synonyms]
RS23597-190HCl
RS 23597-190 hydroch
RS 23597-190 >=98% (HPLC)
RS 23597-190 HYDROCHLORIDE
RS 23597 190 hydrochloride,RS 23597190 hydrochloride
3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL
3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE
3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride
3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride
4-amino-5-chloro-2-methoxybenzoic acid 3-(1-piperidinyl)propyl ester hydrochloride
4-amino-5-chloro-2-methoxy-Benzoic acid 3-(1-piperidinyl)propyl ester hydrochloride (1:1)
Benzoic acid, 4-amino-5-chloro-2-methoxy-, 3-(1-piperidinyl)propyl ester, hydrochloride (1:1) | [Molecular Formula]
C16H24Cl2N2O3 | [MDL Number]
MFCD00672672 | [MOL File]
149719-06-2.mol | [Molecular Weight]
363.28 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Water:36.33(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist. | [Biological Activity]
A high affinity, selective competitive antagonist at 5-HT 4 receptors. | [Biochem/physiol Actions]
RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2). | [in vivo]
RS 23597-190 (6.0 mg/kg; i.v.) inhibits 5-HT-induced tachycardia in micropig[1]. | Animal Model: | Bilaterally vagotomized micropig[1] | | Dosage: | 6.0 mg/kg | | Administration: | I.v. | | Result: | Antagonized 5-HT-induced tachycardia with a half-life of 77 (63-99) min. |
| [IC 50]
5-HT4 Receptor | [storage]
Store at RT |
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