| Hazard Information | Back Directory | [Uses]
Zolbetuximab (development code IMAB362) is an experimental monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. | [Mechanism of action]
Zolbetuximab is the first drug developed against the target of Claudin18.2. It is a chimeric IgG1 monoclonal antibody that specifically binds to Claudin18.2 on the surface of tumor cells, thereby triggering antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), apoptosis and inhibition of cell proliferation. |
|
| Company Name: |
Biolab Reagents Gold
|
| Tel: |
027-65279366 18162686757 |
| Website: |
www.biolabreagent.com/ |
|