| Identification | Back Directory | [Name]
H-TYR-PHE-LEU-LEU-ARG-ASN-PRO-OH | [CAS]
149440-16-4 | [Synonyms]
YFLLRNP
YFLLRNP-OH
HUMAN ALPHA-THROMBIN
YFLLRNP trifluoroacetate
TYR-PHE-LEU-LEU-ARG-ASN-PRO
H-TYR-PHE-LEU-LEU-ARG-ASN-PRO-OH
(Tyr1)-TRAP-7 trifluoroacetate salt
(Tyr?)-TRAP-7 trifluoroacetate salt
ALPHA-THROMBIN ANTAGONIST IN HUMAN PLATELETS
L-Tyrosyl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparaginyl-L-Proline
L-Proline, L-tyrosyl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparaginyl-
(Tyr1)-TRAP-7 trifluoroacetate salt H-Tyr-Phe-Leu-Leu-Arg-Asn-Pro-OH trifluoroacetate salt
YFLLRNP, (Tyr1)-PAR-1 (1-7) (huMan), (Tyr1)-Proteinase Activated Receptor 1 (1-7) (huMan), (Tyr1)-ThroMbin Receptor (1-7) (huMan), (Tyr1)-ThroMbin Receptor Activator Peptide 7, (Tyr1)-Coagulation Factor II Receptor (1-7) (huMan) | [Molecular Formula]
C45H67N11O10 | [MDL Number]
MFCD00238245 | [MOL File]
149440-16-4.mol | [Molecular Weight]
922.08 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
deionized water: soluble1mg/mL | [form ]
solid | [pka]
3.37±0.20(Predicted) | [Water Solubility ]
deionized water: 1mg/mL |
| Hazard Information | Back Directory | [Uses]
YFLLRNP trifluoroacetate may be used as a powerful tool for differentiating the numerous possible activation states of the platelet thrombin receptor. | [Biological Activity]
YFLLRNP is a Galpha12/13-stimulating peptide th at activates the alpha granule secretion due to costimulation with either ADP or serotonin/epinephrine.''YFLLRNP is a PAR-1-specific partial agonist. The compound selectively activates the G(12/13) signaling cascade resulting in platelet shape. |
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