| Identification | Back Directory | [Name]
thioperamide maleate salt | [CAS]
148440-81-7 | [Synonyms]
MR-12842 maleate
N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1) | [Molecular Formula]
C15H24N4SC4H4O4 | [MDL Number]
MFCD00083209 | [MOL File]
148440-81-7.mol |
| Hazard Information | Back Directory | [Description]
Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid. | [Uses]
Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue. | [Biochem/physiol Actions]
Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine. |
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