| Identification | Back Directory | [Name]
DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER | [CAS]
1478-53-1 | [Synonyms]
uoromethanephosphonate
diethyl(difluoromethyl)phosphonate
DIETHYL (DIFLUOROMETHANE)PHOSPHONATE
DIETHYL (DIFLUOROMETHYL)PHOSPHONATE 96%
DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER
P-DifluoroMethylphosphonic Acid Diethyl Ester
1-[difluoromethyl(ethoxy)phosphoryl]oxyethane
Phosphonic acid,P-(difluoromethyl)-, diethyl ester | [Molecular Formula]
C5H11F2O3P | [MDL Number]
MFCD00192023 | [MOL File]
1478-53-1.mol | [Molecular Weight]
188.11 |
| Chemical Properties | Back Directory | [Boiling point ]
96°C 15mm | [density ]
1.193 | [refractive index ]
n20/D 1.388(lit.) | [Fp ]
113 °C | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Clear Colourless | [Specific Gravity]
1.193 | [InChI]
InChI=1S/C5H11F2O3P/c1-3-9-11(8,5(6)7)10-4-2/h5H,3-4H2,1-2H3 | [InChIKey]
VVFGLBKYBBUTRO-UHFFFAOYSA-N | [SMILES]
P(C(F)F)(=O)(OCC)OCC |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless Liquid | [Uses]
Inhibitor of bacterial phosphotriesterases and an intermediate for the synthesis of 5’-diphosphate/5’-triphosphate mimics for transcriptase and glycerol kinase inhibition. | [Synthesis Reference(s)]
Tetrahedron Letters, 23, p. 2323, 1982 DOI: 10.1016/S0040-4039(00)87332-3 | [Synthesis]
Diethyl Difluoromethylphosphonate is prepared by the reaction of sodium diethyl phosphite with Chlorodifluoromethane in hexane (49% yield) or in THF (77% yield) or generated in situ from diethyl bromodifluoromethylphosphonate and BuLi.
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