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ChemicalBook--->CAS DataBase List--->1470018-52-0

1470018-52-0

1470018-52-0 Structure

1470018-52-0 Structure
IdentificationBack Directory
[Name]

AMG2850
[CAS]

1470018-52-0
[Synonyms]

AMG2850
AMG 2850,Inhibitor,AMG2850,inhibit,AMG-2850,Transient receptor potential channels,TRP Channel
((R)-8-(4-(TRIFLUOROMETHYL)PHENYL)-N-((S)-1,1,1-TRIFLUOROPROPAN-2-YL)-5,6-DIHYDRO-1,7-NAPHTHYRIDINE-7(8H)-CARBOXAMIDE)
[Molecular Formula]

C19H17F6N3O
[MDL Number]

MFCD32067868
[MOL File]

1470018-52-0.mol
[Molecular Weight]

417.35
Chemical PropertiesBack Directory
[Boiling point ]

452.7±45.0 °C(Predicted)
[density ]

1.354±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

11.53±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist[1]. TRPM8[1].

[References]

[1]. Lehto SG, et al. AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia. Naunyn Schmiedebergs Arch Pharmacol. 2015 Apr;388(4):465-76.

Spectrum DetailBack Directory
[Spectrum Detail]

AMG2850(1470018-52-0)1HNMR
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