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ChemicalBook--->CAS DataBase List--->146709-78-6

146709-78-6

146709-78-6 Structure

146709-78-6 Structure
IdentificationBack Directory
[Name]

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE
[CAS]

146709-78-6
[Synonyms]

ZD7155HCl
ZD 7155 HYDROCHLORIDE
ZD7155 hydrochloride >=97% (HPLC)
5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride
5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE
[Molecular Formula]

C26H27ClN6O
[MDL Number]

MFCD00921888
[MOL File]

146709-78-6.mol
[Molecular Weight]

474.99
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,2-8°C
[solubility ]

DMSO: 10 mM
[form ]

Powder
[color ]

White to yellow
[Water Solubility ]

Soluble to 10 mM in water with gentle warming
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

ZD 7155 Hydrochloride, is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. it is shown to be more active than the prototype AT1 antagonist, losartan, and it’s orally active.
[Biological Activity]

A potent and selective competitive antagonist for the angiotensin II type 1 (AT 1 ) receptor. Displaces [ 125 I]-angiotensin II binding with an IC 50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT 1 antagonist, losartan.
[storage]

Desiccate at +4°C
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