| Identification | More | [Name]
(S)-tert-Butanesulfinamide | [CAS]
146374-27-8 | [Synonyms]
2-METHYL-2-PROPANESULFINAMIDE
2-METHYL-PROPANE-2-SULFINIC ACID AMIDE
T-BUTYLSULFINAMIDE
TERT-BUTYLSULPHINAMIDE
2-METHYL-2-PROPANESULFINAMIDE, RACEMIC,&
Racemic 2-Methyl-2-propanesulfinamide
TERT-BUTANESULFINAMIDE
(S)-(-)-2-METHYL-2-PROPANESULFINAMIDE, 98+%
(S)-tert-Butanesulfinamide
S-(-)-2-Methyl-2-propanesulfinamide | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C4H11NOS | [MDL Number]
MFCD01863616 | [Molecular Weight]
121.2 | [MOL File]
146374-27-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
97-101 °C(lit.)
| [Boiling point ]
220.0±23.0 °C(Predicted) | [density ]
1.124 | [storage temp. ]
2-8°C | [solubility ]
Soluble in methanol. | [form ]
Powder or Crystals | [pka]
10.11±0.50(Predicted) | [color ]
White to tan | [CAS DataBase Reference]
146374-27-8(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Description]
(S)-tert-Butanesulfinamide (also known as 2-Methyl-2-propanesulfinamide) is used for the synthesis of 4-sulfonyliminopiperidine and its reaction with benzyl Grignard to form an important pharmaceutical building block, 4-benzyl-4-aminopiperidne.It can be also used to prepare spiro tosylaziridines via methylene insertion into the derived sulfonylimine1,2-(R)-(+)-2-Methyl-2-propanesulfinamide may be used to prepare N-(1-cyclohexylmethylidene)-2-methylpropane-2-sulfinamide via copper mediated condensation with cyclohexane carboxaldehyde. It may also be used to prepare (20E)-N-[t-butyl-(R)-sulfinyl]-3β-(t-butyldimethylsilyloxy)-pregn-5-en-20-imine, an intermediate for the development of androgen receptor antagonists. (S)-(-)-2-Methyl-2-propanesulfinamide may be used to develop benzofuran-based farnesyltransferase inhibitors as anti-cancer agents.
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| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
(±)-2-Methyl-2-propanesulfinamide is used in the synthesis of 4-sulfonyliminopiperidine and its reaction with benzyl Grignard to form an important pharmaceutical building block, 4-benzyl-4-aminopiperidne. It is also used to prepare spiro tosylaziridines via methylene insertion into the derived sulfonylimine. |
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