| Identification | Back Directory | [Name]
1H-Benzimidazole, 2-[5-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-furanyl]-, hydrochloride (1:2) | [CAS]
1451058-50-6 | [Synonyms]
DB772
DB-772
DB 772
1H-Benzimidazole, 2-[5-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-furanyl]-, hydrochloride (1:2) | [Molecular Formula]
C20H17ClN4O | [MOL File]
1451058-50-6.mol | [Molecular Weight]
364.83 |
| Hazard Information | Back Directory | [Description]
DB772 is a monocationic inhibitor of scrapie prion accumulation. | [Uses]
DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity[1]. | [References]
[1] James B Stanton, et al. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173. DOI:10.1371/journal.pone.0051173
[2] Benjamin W Newcomer, et al. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96(2):127-9. DOI:10.1016/j.antiviral.2012.09.005
[3] Kelcey D Dinkel, et al. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5467-82. DOI:10.1128/AAC.00811-16 |
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