| Identification | Back Directory | [Name]
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide | [CAS]
1451042-18-4 | [Synonyms]
T247
HDAC3INT247
HDAC3-IN-T247
HDAC3 IN T247
HDAC3 inhibitor T247
HDAC3 inhibitor-T247
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide | [Molecular Formula]
C21H19N5OS | [MDL Number]
MFCD29089340 | [MOL File]
1451042-18-4.mol | [Molecular Weight]
389.47 |
| Chemical Properties | Back Directory | [Melting point ]
236 °C | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
powder to crystal | [pka]
12.39±0.70(Predicted) | [color ]
White to Yellow to Orange |
| Hazard Information | Back Directory | [Uses]
HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 μM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1]. | [IC 50]
HDAC3: 0.24 μM (IC50); HDAC1: 19 μM (IC50); HDAC4: >100 μM (IC50); HDAC6: >100 μM (IC50); HDAC8: >100 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Suzuki T, et al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 2013 Jul 16;8(7):e68669. DOI:10.1371/journal.pone.0068669 |
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