| Identification | Back Directory | [Name]
Pomisartan | [CAS]
144702-17-0 | [Synonyms]
BIBR363
BIBR-363
BIBR 363
Pomisartan
Unii-7539319jyi
Pomisartan [inn]
4'-((2-Ethyl-4-methyl-6-(5,6,7,8-tetrahydroimidazo(1,2-A)pyridin-2-yl)-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid
[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-ethyl-4-methyl-6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)-1H-benzimidazol-1-yl]methyl]- | [Molecular Formula]
C31H30N4O2 | [MDL Number]
MFCD00865868 | [MOL File]
144702-17-0.mol | [Molecular Weight]
490.6 |
| Hazard Information | Back Directory | [Uses]
Pomisartan is an orally active angiotensin II receptor type AT1 antagonist (IC50=0.26 μM). Pomisartan works by inhibiting the binding of angiotensin II to the AT1 receptor, thereby blocking the vasoconstriction and aldosterone release caused by this interaction. Pomisartan results in a blood pressure-lowering effect[1]. | [References]
[1] Krovat EM, et al. Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification. J Med Chem. 2003 Feb 27;46(5):716-26. DOI:10.1021/jm021032v |
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