| Identification | Back Directory | [Name]
Amino-PEG5-t-butyl ester | [CAS]
1446282-18-3 | [Synonyms]
Amino-PEG5-Boc
Amino-PEG5-COOtBu
H2N-PEG5-CH2CH2COOtBu
NH2-PEG5-CH2CH2COOtBu
Amino-PEG5-t-butyl ester
tert-butyl 1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate
4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-amino-, 1,1-dimethylethyl ester | [Molecular Formula]
C17H35NO7 | [MDL Number]
MFCD25424125 | [MOL File]
1446282-18-3.mol | [Molecular Weight]
365.46 |
| Chemical Properties | Back Directory | [Boiling point ]
439.1±40.0 °C(Predicted) | [density ]
1.049±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
8.74±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Amino-PEG5-t-butyl ester is a PEG molecule consisting of an amino group and a t-butyl protected carboxyl group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
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