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ChemicalBook--->CAS DataBase List--->1445830-50-1

1445830-50-1

1445830-50-1 Structure

1445830-50-1 Structure
IdentificationBack Directory
[Name]

BAY-320
[CAS]

1445830-50-1
[Synonyms]

BAY-320
[Molecular Formula]

C26H26F2N6O2
[MDL Number]

MFCD31657346
[MOL File]

1445830-50-1.mol
[Molecular Weight]

492.52
Chemical PropertiesBack Directory
[Boiling point ]

585.0±50.0 °C(Predicted)
[density ]

1.37±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

5.44±0.26(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

BAY-320 is a selective and ATP-competitive Bub1 inhibitor that inhibits the kinase activity of Bub1 with an IC50 of 680 nM. BAY-320 inhibits endogenous Bub1-mediated Sgo1 localization. BAY-320 affects cellular mitotic chromosome arrangement and spindle assembly. BAY-320 inhibits cell proliferation. BAY-320 can be used in the study of cancer[1].
[storage]

Store at -20°C
[References]

[1] Amalina I, et al. Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1. R Soc Open Sci. 2021 Dec 15;8(12):210854. DOI:10.1098/rsos.210854
[2] Baron AP, et al. Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Elife. 2016 Feb 17;5. pii: e12187. DOI:10.7554/eLife.12187
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