| Identification | Back Directory | [Name]
CTX0294885 | [CAS]
1439934-41-4 | [Synonyms]
CS-1944
CS-1885
CTX0294885
CTx0294885, >99%
CTX-0294885, >=98%
CTX-0294885; CTX 0294885; CTX0294885; CTX 0294885.
2-(5-chloro-2-(4-(piperazin-1-yl)phenylaMino)pyriMidin-4-ylaMino)-N-MethylbenzaMide
2-[[5-Chloro-2-[[4-(1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide
Benzamide, 2-[[5-chloro-2-[[4-(1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-
2-(5-chloro-2-(4-(piperazin-1-yl)phenylamino)pyrimidin-4-ylamino)-N-methylbenzamide CTX0294885 | [Molecular Formula]
C22H24ClN7O | [MDL Number]
MFCD28137930 | [MOL File]
1439934-41-4.mol | [Molecular Weight]
437.93 |
| Chemical Properties | Back Directory | [density ]
1.332±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥21.9 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O | [form ]
solid | [pka]
14.57±0.46(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Biological Activity]
ctx-0294885 is a novel bisanilino pyrimidine. it has inhibitory activity towards a wild range of kinases in vitro. ctx-0294885 is capable of capturing more than half of the expressed kinome in mda-mb-231 cells. large-scale ctx-0294885-based affinity purification with lc?ms/ms identifies 235 protein kinases. ctx-0294885 binds additional kinases that were not identified from previous studies using other kinase capture reagents. it is further developed into a sepharose-supported kinase capture reagent. ctx-0294885 is a new tool for analysis of kinome signaling networks. [1] | [References]
1. zhang l, holmes ip, hochgr?fe f et al. characterization of the novel broad-spectrumkinase inhibitor ctx-0294885 as an affinity reagent for mass spectrometry-basedkinome profiling. j proteome res. 2013 jul 5;12(7):3104-16. |
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