| Identification | Back Directory | [Name]
N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE | [CAS]
143360-00-3 | [Synonyms]
SMIP004
CS-1090
SMIP-004
SMIP 004
SMIP 004; SMIP-004
4-N-BUTYL-2-METHYLACETANILIDE
4'-(But-1-yl)-2'-methylacetanilide
N-(4-Butyl-2-methylphenyl)acetamide
N1-(4-BUTYL-2-METHYLPHENYL)ACETAMIDE
Acetamide, N-(4-butyl-2-methylphenyl)-
N-[4-(But-1-yl)-2-methylphenyl]acetamide, 2-Acetamido-5-(but-1-yl)toluene | [Molecular Formula]
C13H19NO | [MDL Number]
MFCD00277686 | [MOL File]
143360-00-3.mol | [Molecular Weight]
205.3 |
| Chemical Properties | Back Directory | [Boiling point ]
343.0±21.0 °C(Predicted) | [density ]
1.003±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥ 20.5 mg/mL in DMSO, ≥ 53.6 mg/mL in EtOH with ultrasonic | [form ]
Solid | [pka]
15.14±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2]. | [Biological Activity]
Cell permeable: yes''Reversible: yes | [in vivo]
SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in SCID mice[2]. | [storage]
Store at -20°C | [References]
[1] Li C, et al. SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. J Exp Clin Cancer Res. 2019 Feb 13;38(1):76. DOI:10.1186/s13046-019-1069-3
[2] Rico-Bautista E, Zhu W, Kitada S, Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via UPR Signaling. Oncotarget. 2013 Jul 14. DOI:10.18632/oncotarget.1130 |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Musechem
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www.musechem.com |
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Twochem Co.Ltd.
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DC Chemicals
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