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      ChemicalBook--->CAS DataBase List--->1431866-33-9

      1431866-33-9

      1431866-33-9 Structure

      1431866-33-9 Structure
      IdentificationBack Directory
      [Name]

      WEHI-539
      [CAS]

      1431866-33-9
      [Synonyms]

      CS-1739
      WEHI-539
      WEHI539;WEHI 539
      WEHI-539 ( CT-WE539)
      (E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr
      5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid
      (E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid
      4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-
      [Molecular Formula]

      C31H29N5O3S2
      [MDL Number]

      MFCD25372044
      [MOL File]

      1431866-33-9.mol
      [Molecular Weight]

      583.72
      Chemical PropertiesBack Directory
      [Boiling point ]

      827.6±75.0 °C(Predicted)
      [density ]

      1.44±0.1 g/cm3(Predicted)
      [storage temp. ]

      Store at -20°C
      [solubility ]

      insoluble in DMSO; insoluble in H2O; insoluble in EtOH
      [form ]

      solid
      [pka]

      10.24±0.20(Predicted)
      Hazard InformationBack Directory
      [Uses]

      WEHI 539 is a selective BCL-XL inhibitor.
      [Biological Activity]

      wehi-539 is a small-molecule inhibitor of bclxlwith an ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xlinhibitor with high affinity. it interacted the with the binding groove of bcl-xlwith a kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. in bcl-xloverexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539can not kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xland mcl-1. [1].
      [target]

      BCL-XL
      [storage]

      Store at -20°C
      [References]

      [1] lessene g, czabotar p e, sleebs b e, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397.
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