成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->1431697-78-7

1431697-78-7

1431697-78-7 Structure

1431697-78-7 Structure
IdentificationBack Directory
[Name]

(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride
[CAS]

1431697-78-7
[Synonyms]

CAL-130 HCl
CAL-130 (Hydrochloride)
(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride
2-[(1S)-1-[(2-Amino-9H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone hydrochloride (1:1)
[Molecular Formula]

C23H23ClN8O
[MDL Number]

MFCD25372043
[MOL File]

1431697-78-7.mol
[Molecular Weight]

462.935
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Biological Activity]

CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor with IC50 of 1.3 and 6.1 nM, respectively.
[in vitro]

CAL-130 preferentially inhibits the function of both p110γ and p110δ catalytic domains. IC 50 values of CAL-130 are 1.3 and 6.1 nM for p110δ and p110γ, respectively, as compared to 115 and 56 nM for p110α and p110β. CAL-130 does not inhibit additional intracellular signaling pathways (ie, p38 MAPK or insulin receptor tyrosine kinase) that are critical for general cell function and survival.

[in vivo]

The clinical significance of interfering with the combined activities of PI3Kγ and PI3Kδ is determined by administering CAL-130 to Lck/Pten fl/fl mice with established T cell acute lymphoblastic leukemia (T-ALL). Candidate animals for survival studies are ill appearing, have a white blood cell (WBC) count above 45,000 μL -1 , evidence of blasts on peripheral smear, and a majority of circulation cells (>75%) staining double positive for Thy1.2 and Ki-67. Mice receive an oral dose (10 mg/kg) of CAL-130 every 8 hr for a period of 7 days and are then followed until moribund. Despite the limited duration of therapy, CAL-130 is highly effective in extending the median survival for treated animals to 45 days as compared 7.5 days for the control group.

[target]

PI3K
1431697-78-7 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135 , +8613564774135
Website:
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Haoyuan Chemexpress Co., Ltd.  
Tel: 021-58950125
Website: http://www.chemexpress.com.cn
Company Name: MedChemexpress LLC  
Tel: 021-58955995
Website: www.medchemexpress.cn
Company Name: AdooQ BioScience, LLC   
Tel: +1 (866) 930-6790
Website: www.adooq.com
Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
Tel: 028-81700200 18116577057
Website: http://www.weikeqi-biotech.com
Company Name: LETOPHARM LIMITED  
Tel: +86-21-5821 5861
Website: www.letopharm.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Guangzhou QiYun Biotechnology Co., Ltd.  
Tel: 020-61288194 61288195
Website: www.gzqiyun.com
Company Name: Musechem  
Tel: +1-800-259-7612
Website: www.musechem.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: http://www.chemegen.com
Company Name: Shanghai Zeye Biotechnology Co., Ltd.  
Tel: 021-61998551 13122364865
Website: m.is0513.com/showsupplierproductslist729391/0.htm
Company Name: Absin Bioscience Inc.  
Tel: 021-38015121 15000105423
Website: www.absin.cn/
Company Name: Shanghai hongqu biomedical technology co. LTD  
Tel: 88888888888
Website: m.is0513.com/ShowSupplierProductsList873228/0.htm
Company Name: MedBioPharmaceutical Technology Inc  
Tel: 021-69568360 18916172912
Website: http://www.med-bio.cn/
Tags:1431697-78-7 Related Product Information