| Identification | Back Directory | [Name]
5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile | [CAS]
1431540-99-6 | [Synonyms]
TC KHNS 11
5-(4-(3-(4-Acetylpiperazine-1-carbonyl)phenyl)quinazolin-6-yl)-2-methoxynicotinonitrile
5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile
3-Pyridinecarbonitrile, 5-[4-[3-[(4-acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy- | [Molecular Formula]
C28H24N6O3 | [MDL Number]
MFCD31689242 | [MOL File]
1431540-99-6.mol | [Molecular Weight]
492.53 |
| Hazard Information | Back Directory | [Uses]
TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor (biochemical IC50 values are 9, 262, 1650 and 4630 nM for PI 3-Kδ, PI 3-Kα, PI 3-Kβ and PI 3-Kγ, respectively; cellular IC50 values are 49, 3440 and 6530 nM for PI 3-Kδ, PI 3-Kα and PI 3-Kβ, respectively). Selective for PI 3-Kδ over a panel of lipid and protein kinases. Inhibits B-cell function. Exhibits moderate oral bioavailability in vivo. | [storage]
Store at -20°C |
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